Postsynaptic synucleins mediate endocannabinoid release, study finds.
A recent study by researchers at Stanford University suggests that the release of endocannabinoids, neurotransmitters that support several vital physiological processes, is supported by postsynaptic synucleins, proteins that have been linked to the development of Parkinson's disease. The study conducted on mice using a series of genetic and imaging techniques found that synuclein deletion blocks endocannabinoid-dependent synaptic plasticity, which could be connected to Parkinson's disease and other neurodegenerative illnesses. The findings could pave the way for further research investigating this connection further, potentially leading to important discoveries.