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Streptothricin

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health2 years ago•2 min saved

Reviving a Forgotten Antibiotic: A Potential Superbug Killer

An antibiotic called streptothricin, developed 80 years ago but abandoned due to toxicity concerns, is being revisited by researchers at Harvard University. Now known as nourseothricin, one of its components, streptothricin F (S-F), has shown promise in killing drug-resistant gram-negative bacteria without toxicity. The antibiotic works by interfering with the protein-making machinery of the bacteria. Researchers hope to enhance streptothricins to develop a new class of antibiotics to combat highly resistant bacteria.

via ScienceAlert|

#antibiotics #drug-resistance #gram-negative-bacteria

health2 years ago•2 min saved

Reviving an Old Antibiotic to Combat Superbugs

An old antibiotic called nourseothricin, derived from a soil fungus, could offer new hope in combating challenging and potentially life-threatening multidrug-resistant bacterial infections. Recent research has demonstrated that different forms of streptothricin, the complex molecule in nourseothricin, exhibit varying toxicities. Streptothricin-F proved less toxic while retaining high activity against contemporary multidrug-resistant pathogens. The researchers unveiled the extensive binding of streptothricin-F to a bacterial ribosome subunit, explaining the translation errors induced by these antibiotics in their target bacteria.

via The Jerusalem Post|

#antibiotics #bacterial-infections #health

health2 years ago•2 min saved

Reviving an Old Antibiotic to Combat Superbugs.

A forgotten antibiotic called streptothricin, which was abandoned due to its toxicity to human kidneys, could be a solution to the emerging threat of drug-resistant superbugs. Researchers have now established that one of its compounds, called S-F, is highly effective at killing drug-resistant gram-negative bacteria but at concentrations that are not toxic. S-F managed to kill off a strain of bacteria that has proved resistant to numerous existing drugs, all with minimal to no toxicity. Researchers are exploring how to enhance natural streptothricins to work even better as superbug killers.

via ScienceAlert|

#antibiotics #drug-resistance #gram-negative-bacteria