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Rna Structures

All articles tagged with #rna structures

science1 year ago•2 min saved

New RNA Structure Linked to Parkinson's Disease Discovered

Researchers at Kumamoto University have discovered that G-quadruplexes (G4s), unique RNA structures, promote harmful protein aggregation in neurodegenerative diseases like Parkinson's. By blocking G4s with 5-aminolevulinic acid (5-ALA), they prevented Parkinson's-like symptoms in mice, suggesting a new treatment avenue. This breakthrough could lead to early interventions for neurodegenerative diseases, potentially extending to conditions like Alzheimer's.

via SciTechDaily|

#5-ala-treatment #neurodegeneration #parkinsons-disease

neuroscience1 year ago•3 min saved

RNA Structures: A New Target for Parkinson's Disease Intervention

Researchers at Kumamoto University have discovered that RNA structures called G-quadruplexes (G4s) promote the aggregation of α-synuclein, a protein linked to neurodegenerative diseases like Parkinson's. Elevated calcium levels trigger these G4s, which act as scaffolds for harmful protein clumping. Administering 5-aminolevulinic acid (5-ALA) to model mice prevented aggregation and reduced motor symptoms, suggesting G4-targeted therapies could offer early intervention for neurodegenerative diseases. This breakthrough may also apply to other conditions involving protein aggregation, such as Alzheimer's.

via Neuroscience News|

#neurodegeneration #neuroscience #parkinsons-disease