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Randomized Clinical Trial

All articles tagged with #randomized clinical trial

medical-research2 years ago

Optimizing Oxygenation: Prone Positioning for Severe ARDS Patients on ECMO

A randomized clinical trial involving 170 patients with severe acute respiratory distress syndrome (ARDS) undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) found that prone positioning did not significantly reduce the time to successful weaning from ECMO compared to supine positioning. The study, primarily consisting of COVID-19 patients, showed that successful ECMO weaning occurred in 44% of patients in both the prone ECMO group and the supine ECMO group. There were no significant differences in secondary outcomes such as mortality, ICU and hospital length of stay, and adverse events between the two groups.

via JAMA Network|
#ards#covid-19#extracorporeal-membrane-oxygenation
medical-research2 years ago

"Landiolol's Impact on Organ Failure in Septic Shock Patients"

A randomized clinical trial involving 126 patients with tachycardia and established septic shock found that the administration of landiolol intravenously to reduce heart rate did not significantly decrease organ failure as measured by the Sequential Organ Failure Assessment (SOFA) score in the 14 days after randomization. The trial was terminated early due to a signal of possible harm and the results do not support the use of landiolol for managing tachycardia among patients treated with norepinephrine for established septic shock.

via JAMA Network|
#landiolol#medical-research#organ-failure
health2 years ago

The Impact of Prenatal Magnesium on Offspring's Neurodevelopment

A randomized clinical trial involving 1433 pregnant individuals at risk of preterm delivery and their 1679 infants found that intravenous magnesium sulfate administered between 30 and 34 weeks' gestation did not significantly reduce the risk of death or cerebral palsy in the children at 2 years of age. While the study showed that magnesium sulfate did not increase the chance of child survival without cerebral palsy, it had limited power to detect small differences between the groups.

via JAMA Network|
#health#magnesium-sulfate#neurodevelopmental-outcomes