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Pyramidal Neurons

All articles tagged with #pyramidal neurons

science5 hours ago•34 min saved

Pyramidal cells steer interneuron fate to shape cortical circuits

A Nature study shows pyramidal neuron subtypes actively sculpt cortical interneuron diversity by promoting their survival and terminal differentiation; in Fezf2 mutants lacking L5b pyramidal neurons, SST interneurons alter programmed cell death and PVALB interneurons switch subtype identity, via activity-independent PN–interneuron signaling and multiple molecular pathways, with a bioinformatic screen identifying candidate ligands and adhesion molecules.

via Nature|

#cortical-development #fezf2 #interneurons

neuroscience2 years ago•4 min saved

"Discovery of Embryonic Brain Circuit May Shed Light on Autism Development"

Researchers have discovered a multi-layer circuit that forms in the cortex during an unexpectedly early stage of development. The circuit initially had two layers, a deep layer and a superficial layer, and was already highly active before the six-layer cortex had formed. The absence of two autism-associated genes caused significant autism in children and resulted in the superficial layer remaining active as a developmental remnant. The findings suggest that changes to embryonic circuits play a role in dysfunctions associated with neurodevelopmental disorders, including autism spectrum disorder.

via Neuroscience News|

#autism #brain-development #embryonic-circuit