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Platelet Factor 4 Pf4

All articles tagged with #platelet factor 4 pf4

health2 years ago

Unraveling the Mystery of Vaccine-Related Blood Clots: New Findings

Researchers from the University of Birmingham have identified the mechanism behind deadly blood clots in patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) following certain COVID-19 vaccinations. The study found that a protein called Platelet factor 4 (PF4) triggers the activation of platelets, leading to clotting. By blocking the receptor triggered by PF4, a drug used to treat blood cancer called ruxolitinib showed potential in protecting VITT patients from clotting. The findings contribute to understanding blood clot formation and may have implications for other related diseases. Ongoing research aims to identify patients at risk of VITT to manage potential risks in future vaccine programs.

health2 years ago

"Revitalizing Aging Brains: Promising Breakthroughs in Blood-based Rejuvenation"

Researchers from the University of California San Francisco (UCSF) and the University of Queensland have identified platelet factor 4 (PF4), a blood factor responsible for blood clot formation, as a key element in rejuvenating the aging brain. Injecting PF4 into aging mice reduced brain inflammation, improved brain cell connections, and enhanced memory and thinking abilities. The study also found that the longevity protein klotho and exercise can stimulate the release of PF4, further improving cognitive abilities in both young and old animals. This research opens up potential avenues for pharmacological interventions to counteract age-related cognitive decline.