All articles tagged with #peptidoglycan
A study suggests that bacterial cell wall molecules like peptidoglycan are present in the brain and fluctuate with sleep cycles, supporting a new 'holobiont condition' model where sleep is regulated by interactions between the brain and microbiome, potentially influencing cognition, behavior, and evolution.
Researchers led by Martin Thanbichler have discovered a central regulator, DipM, that controls different classes of autolysins involved in bacterial cell wall remodeling. DipM interacts with multiple autolysins and a cell division factor, making it the first identified regulator that can control two classes of autolysins. Disruption of DipM leads to cell death, highlighting its critical role in cell shape maintenance and division. These findings may contribute to the development of new therapeutic strategies against bacterial infections by targeting multiple autolytic pathways simultaneously.