Aging gut bacteria linked to memory decline, hinting at gut-targeted therapies
In ageing mice, the bacterium Parabacteroides goldsteinii proliferates and dampens gut-brain signalling, contributing to memory decline; transferring this microbe to young mice worsens memory, while wiping out gut bacteria or targeting P. goldsteinii with phage therapy restores memory, suggesting gut-directed treatments could combat age-related cognitive decline if the mechanism also exists in humans.