Unveiling Surprising Side Effects: Scientists Discover Hidden Dangers of Anti-Cancer Medications
Scientists have discovered that certain anti-cancer drugs can cause unexpected side effects by disrupting the nucleolus, a cellular organelle involved in ribosome biogenesis. By screening over 1,000 existing anti-cancer drugs, researchers identified distinct nucleolar shapes induced by different drug categories, providing a classification system for nucleoli. The study highlights the need to consider the impact on the nucleolus during drug development and could potentially improve the success rate of cancer drug development.