Unraveling Protein Mysteries: Insights into Molecular Dynamics and Brain Diseases
Biophysicists from the University of Konstanz have developed a combination of high-resolution NMR spectroscopy and computer simulations to study the structural dynamics of complex proteins. By examining ubiquitin dimers, they demonstrated the high structural variability of these multi-domain proteins and provided detailed insights into their conformational heterogeneity. This approach opens new avenues for understanding the diverse structures and biological functions of complex proteins.