All articles tagged with #neuropathology
Scientists at the University of New Mexico have identified hidden brain damage linked to vascular dementia, including the presence of nano- and microplastics, which may also contribute to Alzheimer's disease, highlighting the need for new classification and treatment approaches.
A new study highlights the complex role of small blood vessel damage and the presence of microplastics in the brain as contributors to dementia, suggesting the need for revised diagnostic methods and further research into environmental factors affecting brain health.
Researchers have published postmortem data from a woman who died after receiving three doses of the anti-amyloid antibody lecanemab, showing extensive vascular inflammation and numerous ruptured blood vessels throughout her brain. The autopsy revealed that she likely died of complications from lecanemab treatment due to her previously unrecognized risk factors, including being an APOE4 homozygote with severe cerebral amyloid angiopathy. The findings suggest that careful screening for signs of cerebral amyloid angiopathy is crucial for potential immunotherapy patients to avoid similar outcomes. The study also highlights the need for more rigorous baseline evaluation and close monitoring during treatment to prevent severe amyloid-related imaging abnormalities (ARIA).