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Morphic Therapeutic

All articles tagged with #morphic therapeutic

Morphic's oral UC drug shows promise in achieving primary endpoint and spurs Entyvio comparisons.
pharmaceuticals2 years ago

Morphic's oral UC drug shows promise in achieving primary endpoint and spurs Entyvio comparisons.

Morphic Therapeutic has announced positive mid-stage data for its oral med MORF-057 in the ulcerative colitis R&D space, meeting the study's primary goal by showing a statistically significant 6.4-point reduction on a score known as the Robarts Histopathology Index. The biotech hopes it will be an easier option for patients than Takeda's intravenous Entyvio. Meanwhile, Biogen's drug, tofersen, has been granted accelerated approval by the FDA for a rare type of amyotrophic lateral sclerosis, or ALS, giving a small subset of patients a new and much-needed treatment option.

Biogen trims research programs and tops estimates in Q1 earnings report.
biopharma2 years ago

Biogen trims research programs and tops estimates in Q1 earnings report.

Biogen will deprioritize certain gene therapy, stroke and ophthalmology assets as it fine-tunes the pipeline following a recent staff reduction; Morphic Therapeutic touted positive mid-stage data for its oral med for ulcerative colitis; Novartis is shedding around 10% of its pipeline as Vas Narasimhan’s campaign to turn it into a “pure-play” drugmaker goes full steam; the FDA placed a clinical hold on Arbutus Biopharma’s experimental PD-L1 that is designed to treat patients with chronic hepatitis B virus; Vedanta Biosciences has secured $106.5 million to run a Phase III in Clostridioides difficile and a mid-stage trial in ulcerative colitis; Eli Lilly is planning to start testing its weight loss treatment candidate in a head-to-head clinical trial against Novo Nordisk’s Wegovy this month.

healthcare2 years ago

Morphic's MORF-057 Shows Positive Results in UC Main Cohort Study.

Morphic Therapeutic has reported positive topline data from the main cohort of the open-label EMERALD-1 Phase 2a study of MORF-057, an oral small molecule inhibitor of the α4β7 integrin, in adults with moderate to severe ulcerative colitis (UC). MORF-057 achieved the primary endpoint, demonstrating a statistically significant reduction in the Robarts Histopathology Index (RHI) score of 6.4 points (p=0.002) from baseline to week 12. MORF-057 was generally well tolerated at the dose of 100 mg BID (twice daily) with no serious adverse events (SAEs) and no safety signal.