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Molecular Insights

All articles tagged with #molecular insights

healthtech2 years ago•2 min saved

"NIH's Groundbreaking Proteogenomic Dataset Empowers Cancer Researchers in Unraveling Molecular Mysteries"

The National Institutes of Health (NIH) has released a comprehensive proteogenomic dataset that standardizes genomic, proteomic, imaging, and clinical data from over 1,000 tumors across 10 cancer types. This publicly available resource, generated by the Clinical Proteomic Tumor Analysis Consortium (CPTAC), aims to help cancer researchers uncover new molecular insights into cancer development and progression. The dataset supports the Biden-Harris Administration's Cancer Moonshot goal of accelerating cancer research through improved data sharing. Two research papers published by CPTAC investigators demonstrate the dataset's potential for scientific discovery, linking cancer driver mutations with protein patterns and exploring protein modifications that regulate cell signaling and physiology. The pan-cancer proteogenomic dataset can be accessed through the NCI Cancer Research Data Commons repositories.

via National Institutes of Health (.gov)|

#cancer-research #data-sharing #healthtech

science-and-technology2 years ago•3 min saved

The Dual Role of Deubiquitinating Enzymes: Protein Factories and Fubi Proteases

Scientists have discovered that two deubiquitinating enzymes, USP16 and USP36, can also act as proteases for the ubiquitin-like protein Fubi, providing molecular insights into this dual activity. The researchers characterized how these enzymes facilitate the Fubi-controlled maturation of a key protein in the ribosome, the cell's protein factory. This discovery expands our understanding of the mechanisms regulating cellular processes and provides new insights into the role of Fubi in immune signaling. The findings pave the way for better understanding the cellular role of Fubi as a post-translational modification.

via Phys.org|

#cellular-processes #deubiquitinating-enzymes #fubi-proteases