Iron MOF Nanoparticles Deliver Dual ROS Assault, Eradicating Tumors in Mice
OSU researchers developed an iron-based metal‑organic framework nanoagent that triggers two reactive oxygen species—hydroxyl radicals and singlet oxygen—in cancer cells, causing oxidative stress and tumor death while largely sparing healthy tissue. In mice with human breast cancer, the nanoagent accumulated in tumors, produced ROS, and achieved complete tumor regression without systemic toxicity, suggesting broad applicability pending human trials.
