Tag

Mediator

All articles tagged with #mediator

science4 days ago•86 min saved

CFAP20 shields arrested RNAPII from replisome traffic at promoters

CFAP20 prevents promoter-proximal RNAPII arrest from causing clashes with co-directional replisomes, limiting R-loop buildup near replication origins and preserving replication timing. CFAP20 knockout raises promoter R-loops, speeds forks, and reduces origin firing—phenotypes that are rescued by restoring CFAP20 or by removing Mediator/CcNC activity. The protein appears to act in the nucleus to salvage arrested RNAPII, dampening Mediator-driven transcription stress to maintain genome stability.

via Nature|

#cfap20 #mediator #origin-firing

international-relations1 year ago•0 min saved

"Qatar Reassesses Mediator Role in Gaza Cease-fire and Hostage Talks"

Qatar is reconsidering its role as a mediator between Hamas and Israel, a move that could impact the ongoing conflict in the region. This decision comes as Qatar faces pressure from the United States and other Gulf states to distance itself from Hamas, which is considered a terrorist organization by the US and the EU. Qatar has played a significant role in providing financial aid to Gaza and hosting Hamas leaders, but its potential withdrawal as a mediator could have significant implications for the peace process.

via Financial Times|

#hamas #international-relations #israel

law2 years ago•4 min saved

"Fox News and Dominion reach historic settlement in defamation suit"

Veteran mediator Jerry Roscoe was brought in to mediate the defamation lawsuit filed by Dominion Voting Systems against Fox News just hours before the trial was set to begin. After a whirlwind 24 hours of negotiations, a historic deal was reached, with Fox News agreeing to pay $787.5 million and "acknowledging" the court's finding that it repeatedly aired false claims about Dominion. The settlement averted what would have been a high-wattage trial that would have forced the right-wing talk network to reckon further with the election lies it aired in the wake of the 2020 presidential contest.

via CNN|

#defamation-lawsuit #dominion-voting-systems #fox-news