All articles tagged with #mechanotransduction
Originally Published 6 months ago — by Phys.org
Scientists have discovered that mechanical signals from physical activity are transmitted into cells via the endoplasmic reticulum, regulating energy production and tissue health, with implications for injury prevention and treatments for neurodegenerative diseases.
Originally Published 1 year ago — by Medical Xpress
Researchers have discovered that the rare autoimmune disorder CAPS is caused by the overactivation of the NLRP3 inflammasome, which can be influenced by mechanical signaling. This condition, characterized by lifelong symptoms including rashes, joint pain, and hearing loss, has been linked to a protein complex that triggers extreme inflammatory activity. The study suggests that targeting the PIEZO/KCNN4 pathway may offer new therapeutic strategies for treating CAPS and other NLRP3-related inflammatory diseases.