Tag

Liver Inflammation

All articles tagged with #liver inflammation

health1 year ago•2 min saved

"FDA Approves Madrigal Pharmaceuticals' Rezdiffra as First Treatment for Common NASH Liver Disease"

The FDA has approved the first medication, Rezdiffra, for nonalcoholic steatohepatitis (NASH), a common form of liver inflammation associated with obesity and metabolic conditions. The medication, developed by Madrigal Pharmaceuticals, showed promising results in reducing fat accumulation in the liver and achieving NASH resolution with no worsening of fibrosis in clinical trials. It is intended to be used alongside a healthy diet and exercise and is expected to be available next month. The approval marks a significant milestone in NASH treatment and offers hope for patients and healthcare providers.

via CNN|

#fda #health #liver-inflammation

health2 years ago•2 min saved

New therapeutic target discovered for cirrhosis, liver inflammation, and atherosclerosis

Researchers at the University of Barcelona have identified the RNF41 protein as a potential therapeutic target for cirrhosis and liver inflammation. The study found that the expression of RNF41 is lower in macrophages from patients with liver cirrhosis and in mice with liver fibrosis. Restoring the function of RNF41 protein in mice resulted in enhanced elimination of fibrosis, reduced liver inflammation, and increased liver regeneration. The team used innovative techniques, including dendrimer-graphite nanoparticles and specific isolation of macrophages, to obtain these results. Future research will focus on identifying proteins that control RNF41 in macrophages to develop drugs that increase its expression and regulate macrophage activity in liver diseases.

via Medical Xpress|

#cirrhosis #health #liver-inflammation

health2 years ago•2 min saved

AAV2 virus causes severe hepatitis outbreak in children.

More than 1,000 cases of childhood hepatitis with no known cause have been reported since 2022. Three independent studies have now linked the outbreak to infection by adeno-associated virus 2 (AAV2). The cases were often serious, with 7.3% of affected children needing a liver transplant. The discovery of AAV2 in the blood and livers of such children might provide an explanation and could influence disease management.

via Nature.com|

#aav2-virus #children #disease-management