Tag

Lineage Plasticity

All articles tagged with #lineage plasticity

cancer-research3 months ago•113 min saved

New Insights into Lung Cancer Origins and Lineage Plasticity

The study reveals that basal lung epithelial cells can give rise to diverse subtypes of small cell lung cancer (SCLC), including neuroendocrine and tuft-like states, with lineage plasticity driven by genetic factors like MYC and PTEN loss. Loss of ASCL1 promotes tuft-like POU2F3+ SCLC, and lineage tracing confirms transitions between subtypes, highlighting the role of cell of origin and genetic alterations in SCLC heterogeneity and plasticity.

via Nature|

#ascl1 #basal-cells #cancer-research

health1 year ago•5 min saved

"Vitamin A's Crucial Role in Stem Cell Biology, Wound Healing, and Cancer Development"

New research suggests that retinoic acid, the biologically active form of Vitamin A, plays a crucial role in regulating lineage plasticity in stem cells, particularly in the context of wound repair and hair regeneration. The study found that retinoic acid is essential for stem cells to exit lineage plasticity and differentiate into hair or epidermal cells, with implications for understanding skin and hair disorders, as well as potential applications in cancer treatment. The findings shed light on the complex role of Vitamin A in orchestrating stem cell lineage choices and have the potential to transform the study of hair biology and improve prognoses for certain types of cancer.

via Phys.org|

#health #lineage-plasticity #skin-biology