All articles tagged with #integrated stress response
Scientists at the University of Manchester have discovered that the Integrated Stress Response (ISR), a cellular mechanism activated under stress, can restrict hair growth by halting cell division and causing mitochondrial dysfunction. This finding, published in PLOS ONE, suggests that targeting ISR could lead to new treatments for hair loss.
Scientists at Scripps Research have discovered a mitochondrial protein structure, composed of the DELE1 protein, that is crucial for activating the cell's integrated stress response (ISR). This finding could have implications for the development of therapeutics for age-related diseases, such as neurodegeneration. The researchers identified that the DELE1 protein forms an octamer, or an oligomeric structure, which is necessary for initiating the ISR. Understanding and manipulating this pathway could lead to potential treatments for various disorders.