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Ibd Segments

All articles tagged with #ibd segments

science-and-technology2 years ago•3 min saved

Unprecedented Precision: Ancient DNA Unveils Distant Relatives

Researchers have developed a new tool called "ancIBD" that can extract Identity by Descent (IBD) segments from ancient genomes, allowing them to detect biological relatives in ancient DNA. By filling in gaps in degraded ancient genomes using modern reference DNA panels, the researchers were able to identify hundreds of previously undetected pairs of relatives in a dataset of 4,248 ancient genomes. The tool also revealed connections between ancient cultures and provided insights into the mobility of past populations. This advancement in screening ancient DNA for parental relatedness will contribute to a better understanding of our ancestors' lives and large-scale cultural-historical events.

via Phys.org|

#ancestry #ancient-dna #genetic-relatives

science-and-technology2 years ago•52 min saved

Uncovering Ancient Genetic Connections with Unprecedented Accuracy

Researchers have developed a method called ancIBD to accurately detect identity-by-descent (IBD) segments in human ancient DNA (aDNA) data. IBD segments are long genomic segments that are co-inherited from a recent common ancestor and can provide valuable information about genealogical connections and demographic history. The ancIBD method utilizes phased genotype likelihoods imputed by GLIMPSE and a hidden Markov model (HMM) to infer IBD blocks. The researchers evaluated the performance of ancIBD on simulated and downsampled aDNA data, demonstrating its robustness in detecting IBD segments even at low coverage depths. They also used ancIBD to identify biological relatives and uncover genealogical connections among ancient Eurasian individuals, shedding light on ancient migration patterns and population interactions.

via Nature.com|

#ancient-dna #genetic-relationships #genomic-analysis