Uncovering Ancient Genetic Connections with Unprecedented Accuracy
Researchers have developed a method called ancIBD to accurately detect identity-by-descent (IBD) segments in human ancient DNA (aDNA) data. IBD segments are long genomic segments that are co-inherited from a recent common ancestor and can provide valuable information about genealogical connections and demographic history. The ancIBD method utilizes phased genotype likelihoods imputed by GLIMPSE and a hidden Markov model (HMM) to infer IBD blocks. The researchers evaluated the performance of ancIBD on simulated and downsampled aDNA data, demonstrating its robustness in detecting IBD segments even at low coverage depths. They also used ancIBD to identify biological relatives and uncover genealogical connections among ancient Eurasian individuals, shedding light on ancient migration patterns and population interactions.