
Glute Shape Signals Diabetes Risk, With Sex-Specific Differences
A UK Biobank study of 61,290 MRI scans used surface-to-surface analysis to link gluteus maximus morphology to type 2 diabetes risk, finding men with T2D tend to have a flattened, atrophied glute, while women show outward bulging from fat deposition. Larger gluteus maximus at baseline linked to lower future diabetes risk after adjusting for age, BMI, and lifestyle. The findings suggest muscle phenotype, not just quantity, matters for diabetes risk and could inform clinical assessments, though MRI-based shape analysis is not scalable for routine care and requires further longitudinal validation.
