All articles tagged with #gene splicing
William J. Rutter, a pioneer in biotechnology and founder of Chiron Corporation, played a key role in developing gene-based medicines, including the first genetically engineered vaccine and treatments for diseases like hepatitis B, HIV, and multiple sclerosis. He passed away at 97 due to cancer complications, leaving a legacy as a founder of the biotech industry and a scientist with over 380 publications and numerous patents.
Researchers have identified three novel genes that contribute to neurodevelopmental disorders by impacting the spliceosome, a protein complex responsible for gene splicing. Through genomic sequencing, phenotyping, and modeling in fly and stem cells, the study revealed the malfunction of these genes in conditions such as developmental delay, intellectual disability, and autism. This breakthrough provides a deeper understanding of the genetic mechanisms behind neurodevelopmental disorders and opens up potential therapeutic targets for future treatments.