Uncovering Genetic Risks of Cannabis Use Disorder: A Comprehensive Study
Scientists have identified gene variants associated with the risk of developing cannabis use disorder, a condition characterized by tolerance to cannabis and difficulty in cutting back despite negative consequences. The study analyzed the genomes of over 1 million individuals, including those of European, African, East Asian, and mixed ancestries, and found key genetic hotspots associated with the disorder. These hotspots were often located near genes related to neurons and the brain's reward system, suggesting a role for dopamine receptors in addiction. The study also revealed links between cannabis use disorder and smoking cigarettes, substance dependence, PTSD symptoms, and a potential genetic link to lung cancer. Further research is needed to understand these associations fully.
