"GABAergic Neurons: Key Players in Glucose-Dependent Insulinotropic Polypeptide's Control of Body Weight and Food Intake in Mice"
Glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake through GABAergic neurons, according to a study in mice. The study found that GIPR agonism is a vital component of GIPR-GLP-1R co-agonism, which has been effective in treating obesity and diabetes. Mice with Gipr deletion in inhibitory GABAergic neurons showed decreased body weight, improved glucose metabolism, and decreased food intake. The study also revealed that GIP acts on hindbrain GIPR neurons to regulate food intake, and GIP requires GIPR signaling in inhibitory GABAergic neurons to decrease food intake. These findings provide insights into the mechanisms underlying the metabolic effects of GIP and GIPR-GLP-1R co-agonism.
