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Fmrp

All articles tagged with #fmrp

neuroscience2 years ago•5 min saved

The Impact of mRNA Transport on Neuronal Well-being

Researchers have discovered a link between mRNA transport and the survival and pathology of sensory neurons. They found that the Dynein Roadblock 1 (Dynlrb1) subunit of the dynein protein complex is critical for neuron survival and the transport of vital molecules. They also identified the role of FMRP in mRNA transport, which offers a more energy-efficient method than transporting proteins. Dysfunctions in this system could provide insights into certain neuropathologies.

via Neuroscience News|

#dynein-protein-complex #fmrp #mrna-transport

neuroscience2 years ago•6 min saved

Pre-Birth Protein Deficiency Unveils Fragile X Syndrome Development

Fragile X syndrome (FXS), the leading form of inherited intellectual disability, has been found to develop before birth due to a deficiency in the protein FMRP, which plays a crucial role in mitochondrial function during prenatal development. Researchers discovered that brain cells damaged by the lack of FMRP can be rescued by enhancing mitochondrial function, offering potential avenues for early intervention and treatment strategies. The study also identified the regulatory role of FMRP on the RACK1 gene, highlighting the importance of prenatal development in FXS and providing a molecular link between FXS and autism spectrum disorder.

via Neuroscience News|

#fmrp #fragile-x-syndrome #mitochondria