Tag

Exercise Intolerance

All articles tagged with #exercise intolerance

health2 years ago•4 min saved

"Mitochondrial Damage and T Cell Dysregulation: Unraveling the Mysteries of Long COVID Symptoms"

A study suggests that people with long COVID exhibit alterations in their muscle structure, with a higher proportion of fatiguable muscle fibers and dysfunctional mitochondria, leading to reduced exercise capacity and worsening symptoms after physical activity. The presence of microclots in muscles and locally activated immune cells indicates tissue damage and inflammation. Targeting mitochondria with compounds like coenzyme Q10 may improve symptoms, highlighting the need for caution in rehabilitation strategies for long COVID sufferers.

via The Conversation Indonesia|

#exercise-intolerance #health #long-covid

health2 years ago•3 min saved

The Connection Between Protein and Exercise Intolerance in ME/CFS

A study conducted by NIH researchers suggests that high levels of a protein called WASF3 may reduce energy production in the muscle cells of people with ME/CFS, leading to exercise intolerance. Blocking this protein in lab cells restored energy production, indicating a potential new strategy for treating the condition. The study also found substantially higher levels of WASF3 in muscle tissue samples from people with ME/CFS compared to healthy volunteers. The dysfunctional increase in WASF3 appeared to be linked to impairment of a cellular signaling pathway called the ER stress pathway. Further research is needed to determine if targeting ER stress could be a promising approach for ME/CFS and other conditions associated with fatigue.

via National Institutes of Health (.gov)|

#exercise-intolerance #health #mecfs