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Ddhd2

All articles tagged with #ddhd2

New Discovery Reveals Fat as Key Fuel for Brain Health and Disease Treatment

Originally Published 3 months ago — by Neuroscience News

Scientists discovered that neurons can burn fat for energy and produce their own fats during high demand, a process dependent on DDHD2. In conditions like HSP54, where DDHD2 malfunctions, neurons lose this ability, but fatty acid supplements can restore their function within 48 hours, offering hope for neurodegenerative disease treatments.

health science ddhd2 fat-metabolism hsp54 neurodegeneration neurons science

DDHD2's Role in Supplying Saturated Fats for Brain Energy and Function

Originally Published 3 months ago — by Nature

The study reveals that DDHD2 enzyme releases saturated fatty acids like myristic, palmitic, and stearic acids, which fuel mitochondrial beta-oxidation to support neuronal energy production. Loss of DDHD2 impairs this pathway, leading to reduced ATP, mitochondrial dysfunction, and neurological deficits akin to hereditary spastic paraplegia. Supplementing with CoA-conjugated fatty acids restores mitochondrial function and may offer a therapeutic approach for HSP54.

health science ddhd2 hereditary-spastic-paraplegia mitochondrial-function neuronal-energy saturated-fatty-acids science