All articles tagged with #cytokine storm
Researchers developed a human lung-on-a-chip model incorporating immune cells to better study severe influenza infection, revealing how immune components influence viral replication, tissue damage, and cytokine responses, and identifying potential therapeutic targets like IL-1β and TNF-α pathways.
Secondary bacterial pneumonia, rather than cytokine storm, is a significant factor in COVID-19-related fatalities, according to a recent study that challenges the widely-held belief. Almost half of the patients who required mechanical ventilation support were affected by this secondary bacterial infection. By applying machine learning to analyze medical records, the researchers found that those who recovered from secondary pneumonia were more likely to survive, whereas unresolved cases increased mortality risk. The study emphasizes the importance of preventing and aggressively treating secondary bacterial pneumonia in critically ill patients.
Scientists at Northwestern University Feinberg School of Medicine have found that secondary bacterial pneumonia that does not resolve was a key driver of death in patients with COVID-19, affecting almost half the patients who required support from mechanical ventilation. The study also debunks the theory that COVID-19 causes a “cytokine storm” leading to death. The scientists developed a new machine learning approach called CarpeDiem, which groups similar ICU patient-days into clinical states based on electronic health record data.