Repurposed Antiemetic May Restore Brain’s Inhibitory Brake to Curb Epilepsy
Researchers identified two molecules, prochlorperazine and CLP-257, that stabilize the KCC2 chloride transporter to restore GABAergic inhibition in epileptic tissue. In human brain slices they nearly abolished spontaneous interictal spikes, and in mouse models they reduced seizure frequency by about 40–55%, suggesting a promising repurposing path for treatment-resistant temporal lobe epilepsy (potentially in combination with benzodiazepines).