Tag

Cbass

All articles tagged with #cbass

health1 year ago

"Novel Strategy Unveiled for Combatting Bacterial Infections"

Researchers at Icahn Mount Sinai have discovered a new approach to combat bacterial infections by harnessing the self-killing activity of bacteria through the cyclic oligonucleotide-based antiphage signaling system (CBASS). By activating the bacterial defense mechanism, they found a way to control infections and potentially manage antibiotic resistance. The team's findings, published in Nature Structural & Molecular Biology, could lead to innovative tools for fighting superbugs and staying ahead of evolving drug resistance.

science-and-technology2 years ago

Bacterial cGAS: Triggering Immunity with Viral RNA

Bacterial cyclic GMP-AMP synthase (cGAS) in the CBASS system senses viral RNA to initiate immunity in bacteria. Researchers investigated the activation mechanism of type I CBASS cyclases in staphylococci and found that a viral RNA, called cabRNA, activates the cyclase Ssc-CdnE03. The cabRNA contains secondary structures that are essential for cyclase activation. Mutations in positively charged residues of the cyclase disrupt the binding of cabRNA and impair cGAMP production. The study also revealed that other cyclases, such as Sha-CdnE01, from different CBASS systems can also be activated by cabRNA.