Uncovering the Secrets of Cell Division Reversal in Cancer Treatment
Researchers at the Center for Molecular Medicine Norway have discovered the mechanisms behind the activation of Aurora B, an enzyme crucial for cell division. By disrupting the activity of Aurora B during cell division, the process becomes chaotic, leading to cell death. This knowledge can be used to develop new cancer treatments that block Aurora B activity and prevent cancer cells from dividing uncontrollably. The researchers used molecular dynamics simulation and hydrogen-deuterium exchange mass spectrometry to analyze the structure and dynamics of Aurora B.