"Targeting Immune Cell Exhaustion to Combat Alzheimer's Neurodegeneration"
New research suggests that exhausted immune cells in the brain, known as TIM, may play a key role in driving Alzheimer's disease, particularly in individuals with the APOE4 gene variant. The study found that these immune cells lose their ability to efficiently remove plaque from the brain, contributing to Alzheimer's. Additionally, the Alzheimer's drug aducanumab was found to improve the condition of these exhausted cells, particularly in mice with the APOE4 variant. The findings may lead to the development of novel Alzheimer's therapies targeting these exhausted immune cells.
