Unveiling the Human Protein Shield Against Bird Flu
Mutations in the viral genome of avian influenza A viruses have been discovered that can overcome a newly discovered antiviral protein, BTN3A3, in human cells. BTN3A3 inhibits a crucial step needed for viral replication, making it difficult for the viruses to cross the species barrier from birds into humans. This finding provides insights into mechanisms that prevent the spillover of avian influenza viruses and could contribute to the development of strategies to combat potential pandemics.