"Uncommon Gene Mutation Provides Alzheimer's Protection for Woman"
A Colombian woman who carried a genetic defect for Alzheimer's disease remained cognitively healthy into her 70s due to possessing two copies of a rare gene mutation known as the Christchurch mutation in the APOE gene. Researchers replicated this mutation in a mouse study and found that it breaks the link between amyloid beta accumulation and cognitive decline, preventing the accumulation of tau protein. This discovery could lead to new methods for preventing Alzheimer's dementia by mimicking the effects of this mutation to halt the disease's progression.
