All articles tagged with #amphotericin b
Peter Redweik's severe illness after treatment for cryptococcal meningitis was caused by an autoimmune inflammatory response to dead fungus particles, not a recurrence of infection. Advanced diagnostics at the NIH helped identify this condition, leading to effective steroid treatment and recovery, despite lasting impairments.
Researchers have developed a renal-sparing polyene antifungal by tuning the sterol extraction kinetics. The study focused on amphotericin B, a potent antifungal drug that can cause kidney damage. By modifying the drug's structure, the researchers were able to reduce its toxicity while maintaining its antifungal activity. This development is significant as fungal infections pose a growing threat, and the need for safer and more effective antifungal drugs is crucial.