All articles tagged with #adjuvants
US health officials are reviewing the safety of aluminium in vaccines amid political statements by Trump, who has called for its removal, despite scientific consensus that aluminium adjuvants are safe and have been used for decades to enhance vaccine efficacy. Removing aluminium would be complex, potentially reducing vaccine effectiveness and risking outbreaks of preventable diseases.
Researchers at MIT and Scripps have developed a promising HIV vaccine approach using two adjuvants that elicit a strong, diverse immune response with just one dose, potentially revolutionizing vaccine strategies for HIV and other infectious diseases.
Researchers have found that enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines can be achieved by adjuvanting both the ionizable lipid and the mRNA. Adjuvants such as lipid nanoparticles have been shown to induce robust T follicular helper cell and humoral responses, leading to increased efficacy of mRNA and protein subunit vaccines. Additionally, the use of heterocyclic lipids in mRNA delivery has been found to activate immune cells through the STING pathway, further enhancing anti-tumor efficacy. The optimization of lipid nanoparticles for mRNA vaccine delivery and the use of adjuvants like ionizable cationic lipid nanoparticles have the potential to improve the immune response and efficacy of mRNA vaccines against COVID-19 and other diseases.
Chinese researchers have developed two innovative adjuvants using computer-aided molecular design and machine learning that significantly amplify the immune response to vaccines, leading to improved immunization against certain forms of cancer in animal models. The adjuvants are designed to bind to toll-like receptors (TLR), a class of proteins used by dendritic cells to detect the characteristic molecular patterns of pathogens. The new adjuvants have broad-spectrum effectiveness and could reduce the problem of decreasing immunity for current vaccines and perhaps make booster vaccines unnecessary. Their use in immunotherapy to treat cancer is also highly promising.