Unveiling the Intricate Link Between Neural Connections and Cognitive Adaptability
Researchers have discovered a specific type of neuronal connection in the prefrontal cortex, formed by inhibitory neurons, that plays a crucial role in updating our understanding of the world and its rules. These inhibitory neurons were found to communicate with neurons located far away in the opposite hemisphere of the prefrontal cortex. When these long-distance inhibitory neuronal connections were deactivated in mice, the mice were unable to adapt to changes, providing insights into conditions such as schizophrenia, bipolar disorder, and autism spectrum disorder, where patients struggle with adapting to change. This finding enhances our understanding of brain function and could have implications for studying and treating these psychiatric conditions.