New Progeroid Neuropathy Reveals Actin Scaffolding Failure in Aging Brain
Researchers identify a homozygous IVNS1ABP mutation that creates a progeroid syndrome with severe neurological decline. By reprogramming patient cells into iPSCs and neural progenitors, they show the mutation disrupts actin dynamics during cell division, causing DNA damage and cellular senescence; in lab models, actin-stabilizing compounds partly fix division defects and improve cell growth, pointing to a potential drug target for this rare disease.