Gene-edited pig kidney extends monkey's life for 2 years, paving the way for improved human transplants

In a groundbreaking trial, researchers successfully transplanted genetically modified pig kidneys into monkeys, resulting in record-long survival times. The study, published in the journal Nature, offers hope for addressing the shortage of human organ donors and the high mortality rates associated with kidney failure. The genetically modified pigs had three critical gene modifications, including the removal of antigens that trigger organ rejection and the insertion of human genes to regulate rejection pathways. The combination of gene edits and immunosuppressive drugs allowed the transplanted kidneys to function effectively, with some monkeys surviving for over two years. The researchers plan to collaborate with the FDA to initiate human clinical trials in the near future, although safety concerns and regulatory challenges remain.