Tuberculosis Stages a Modern Comeback in the U.S., Raising Drug-Resistance Fears

TB is resurging in the United States, with provisional 2025 data showing 10,260 cases nationwide (967 in New York). The disease often exists as latent infections (up to 13 million nationwide) that can activate, fueling spread and antibiotic resistance (589 cases resistant to at least one frontline drug in 2023). Active and latent TB require long antibiotic regimens (6–9 months), and early detection plus vaccination considerations are key to prevention. Globally TB remains one of the deadliest infectious diseases, underscoring the ongoing public-health challenge in America and beyond.