Breakthrough Discovery Unveils Major Cause of Inflammatory Bowel Disease

TL;DR Summary
UK scientists have identified a genetic weak spot present in 95% of people with inflammatory bowel disease (IBD), which causes immune cells to drive excessive inflammation in the bowels. Existing drugs have shown promise in reversing the disease in lab experiments, and researchers aim to start human trials within five years. This discovery could lead to new treatments for conditions like Crohn's disease and ulcerative colitis, which affect around half a million people in the UK.
Topics:top-news#clinical-trials#crohns-disease#genetic-research#health#inflammatory-bowel-disease#macrophages
- Major cause of inflammatory bowel disease found BBC.com
- A disease-associated gene desert directs macrophage inflammation through ETS2 Nature.com
- Bowel disease breakthrough as researchers make ‘holy grail’ discovery The Guardian
- Inflammatory bowel disease: 'Massive step forwards' as major cause of IBD discovered Sky News
- Major cause of inflammatory bowel disease discovered Medical Xpress
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