"Key Role of HKDC1 Protein in Sustaining Mitochondrial and Lysosomal Integrity Uncovered"

Researchers at Osaka University have discovered that the protein HKDC1, regulated by TFEB, is essential for maintaining the health of mitochondria and lysosomes within cells. HKDC1 supports mitophagy by stabilizing PINK1 in collaboration with TOM70 and is crucial for the repair of damaged lysosomes through its interaction with VDAC proteins. This protein's role in preserving mitochondrial and lysosomal function is key to preventing cellular senescence, offering potential new therapeutic targets for aging and related diseases. The findings were published in the journal PNAS.