"Deciphering the Function of FAM81A Protein in Synaptic Mechanisms"

Researchers at Kobe University have identified FAM81A as a critical protein involved in forming postsynaptic protein agglomerations essential for synaptic function in the brain. FAM81A interacts with key postsynaptic proteins, regulates their assembly, and impacts neuron function through liquid-liquid phase separation. The protein's presence in the postsynaptic density suggests its significance in maintaining synaptic activity, providing insights into synaptic mechanisms and the evolution of cognitive functions in higher vertebrates. This discovery opens new avenues for exploring potential implications for neuropsychiatric conditions.