Uncovering Mechanisms of Beta Cell Dysfunction in Type 2 Diabetes through Multiomic Measurements and Genetics Integration.

Integrating genetics with single-cell multiomic measurements across disease states has identified mechanisms of beta cell dysfunction in type 2 diabetes. The study found that beta cells in type 2 diabetes patients have reduced expression of genes involved in insulin secretion and glucose metabolism, and increased expression of genes involved in stress response and inflammation. The findings provide insights into the underlying mechanisms of beta cell dysfunction in type 2 diabetes and could lead to the development of new treatments.