Isomer of Benzene gains prominence in organic synthesis.

Researchers have demonstrated that the high energy compound 1,2,3-cyclohexatriene, an overlooked isomer of benzene, can participate in a diverse range of cycloaddition, nucleophilic addition, and σ-bond insertion reactions, enabling chemists to construct complex molecular architectures in just a few steps. The team hopes that its work inspires others to explore and exploit the synthetic potential of these high-energy reagents going forwards.