Zoonotic Jumps Often Happen Without Special Viral Tweaks
TL;DR Summary
An analysis of outbreaks of influenza A, Ebola, Marburg, mpox, SARS-CoV, and SARS-CoV-2 finds no pre-spillover adaptive mutations; natural selection is normal in animal reservoirs and remains stable before spillover, with most changes occurring after human transmission begins; the study also notes a lab-origin signal for the 1977 H1N1 pandemic, but overall emphasizes reducing exposure and boosting surveillance to prevent future spillovers.
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- Genetic signatures in SARS-CoV-2 show no evidence of lab origin 동아사이언스
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