SLIT3 Wiring in Brown Fat Boosts Calorie Burning and Heat Production
TL;DR Summary
A Nature Communications study reveals brown fat uses SLIT3 fragments, produced by BMP1, to drive blood vessel and nerve growth essential for thermogenesis. In mice, removing SLIT3 or its receptor PLXNA1 impairs nerve and vascular networks and lowers heat production, while human fat analyses suggest SLIT3 activity may influence obesity and insulin sensitivity, pointing to therapies that increase energy expenditure rather than curb appetite.
- Scientists Discover Protein That Turns Brown Fat Into a Calorie-Burning Machine SciTechDaily
- Discovery of pathway that activates brown fat could lead to new obesity treatment Medical Xpress
- SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue Nature
- Brown fat cells with blood vessels and nerves (IMAGE) EurekAlert!
- Fat cells burn energy to make heat – making them the next frontier of weight loss therapies The Hindu
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