Gut Cells Prime Immune Attack in Multiple Sclerosis
TL;DR Summary
A Keio University–led study shows intestinal epithelial cells in the ileum upregulate MHC II to prime pathogenic Th17 cells, which migrate from the gut to the CNS and drive neuroinflammation in MS; findings in mice and human biopsies suggest the gut as a therapeutic target alongside existing MS treatments.
- How Intestinal Cells Trigger Multiple Sclerosis Neuroscience News
- Gut 'primes' pathogenic T cells responsible for neuroinflammation in multiple sclerosis, study finds Medical Xpress
- Gut Inflammation Could Contribute to Multiple Sclerosis the-scientist.com
- Gut Cells May Be Training Immune Troops to Attack the Brain ScienceBlog.com
- Gut-Immune Link Identified in Multiple Sclerosis-Related Neuroinflammation Genetic Engineering and Biotechnology News
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