Redefining Gain-of-Function Research: A Fresh Perspective

Gain-of-function research in the field of life sciences involves conferring new or additional traits to organisms, and it encompasses a wide range of work with potential benefits for society. While concerns about the modification of pathogens to increase their infectivity or severity are valid, focusing solely on the risks hinders progress and overlooks the potential benefits of gain-of-function research. It is crucial to strike a balance between innovation and safety, communicate effectively to address misinformation, enhance science literacy, and foster collaboration between scientists, biosecurity and biosafety communities, and policymakers to ensure that research is conducted safely and securely.